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MDA-19 is a cannabinoid receptor agonist that operates as a powerful and selective agonist for CB2, with considerable selectivity over the psychoactive CB1 receptor. However, there is some variance between species. It was successful in treating neuropathic pain in animals, but it did not elicit cannabis-like behavioral effects. At Legit Cannabinoids, we are available with MDA-19 for sale at the best rates. You can place your Order MDA-19 online and receive it shortly!
What are the Qualities of MDA-19?
MDA19 had a 4-fold higher affinity for the human CB (2) receptor than the human CB1 receptor (K(i) = 43.3 +/- 10.3 vs 162.4 +/- 7.6 nM), and a roughly 70-fold higher affinity for the rat CB2 receptor than the rat CB1 receptor (K(i) = 16.3 +/- 2.1 vs 1130 +/- 574 nM).
MDA19 acted as an agonist at the human CB1 and CB2 receptors, as well as the rat CB1 receptor, in guanosine triphosphate (GTP)gamma [(35) S] functional tests, but as an inverse agonist at the rat CB2 receptor.
MDA19 acted as an agonist at the rat CB1 receptor in 3′,5′-cyclic adenosine monophosphate (cAMP) tests but had no functional action at the rat CB (2) receptor. Activation tests for extracellular signal-regulated kinases 1 and 2.
MDA19 acted as an agonist at the CB2 receptor in rats. In rats and CB2(+/+) mice, MDA19 reduced tactile allodynia caused by spinal nerve ligation or paclitaxel in a dose-dependent manner, but not in CB2(-/-) mice, showing that MDA19 was mediated by CB2 receptors. MDA19 had no effect on rat locomotion.
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