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Etizolam is a thienodiazepine derivative that acts on the benzodiazepine receptor, making it a benzodiazepine. Etizolam suppliers, buy etizolam powder, etizolam powder suppliers, etizolam for sale, etizolam powder wholesale from China.
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Etizolam increases GABAergic transmission and enhances GABA-induced Cl- currents by acting as a complete agonist at GABA-A receptors. It is thought to bind to the benzodiazepine binding site, which is positioned across the alpha-gamma subunit interface. According to reports, benzodiazepines only bind to receptors that contain the gamma 2 and alpha 1/2/3/5 subunits.
Etizolam sedative effects are mediated by alpha-1 receptors, and the anxiolytic action is mediated by alpha-2 and alpha-3 subunit-containing receptors. With the alpha 1 beta 2 gamma 2S subunit combination, Etizolam has high efficacy and affinity for the GABA-A receptor.
Etizolam increases GABA transmission by promoting the opening of GABA-induced chloride channels by binding to the receptor’s regulatory region. Etizolam is a particular PAFR antagonist. With an IC50 of 22nM, it inhibits PAF-induced platelet aggregation by blocking PAF binding to receptors on platelet surfaces.
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Etizolam is a central nervous system depressant with anxiolytic, anticonvulsant, sedative-hypnotic, and muscle relaxant properties. As an agonist, it increases inhibitory GABAergic transmission throughout the central nervous system by binding to the benzodiazepine region of the GABA-A receptor. According to studies, Etizolam appears to have 6 to 10 times the potency of diazepam in mediating its pharmacological activities.
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